Background. To evaluate the efficacy and acceptability of orthokeratology for slowing myopic progression in children with a well\nconducted evidence-based analysis. Design. Meta-analysis. Participants. Children from previously reported comparative studies\nwere treated by orthokeratology versus control. Methods. A systematic literature retrieval was conducted in MEDLINE, EMBASE,\nCochrane Library,World Health Organization International Clinical Trials Registry Platform, and ClinicalTrials.gov.The included\nstudies were subjected to meta-analysis using Stata version 10.1.Main Outcome Measures.Axial length change (efficacy) and dropout\nrates (acceptability) during 2-year follow-up. Results. Eight studies involving 769 subjects were included. At 2-year follow-up, a\nstatistically significant difference was observed in axial length change between the orthokeratology and control groups, with a\nweighted mean difference (WMD) of ?0.25mm (95% CI, ?0.30 to ?0.21). The pooled myopic control rate declined with time,\nwith 55, 51, 51, and 41% obtained after 6, 12, 18, and 24 months of treatment, respectively. No statistically significant difference was\nobtained for dropout rates between the orthokeratology and control groups at 2-year follow-up (OR, 0.79; 95% CI, 0.52 to 1.22).\nConclusions. Orthokeratology is effective and acceptable for slowing myopic progression in children with careful education and\nmonitoring.
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